Salivary buffer and diabetes
Mickenautsch S*, Yengopal V*, Bonecker M**, Oliveira LB***
*Division of Public Oral Health, University of the Witwatersrand, Johannesburg, South Africa
**Department of Orthodontics and Paediatric Dentistry, University of São Paulo, Brazil
***São Leopoldo Mandic Research Center, Campinas, São Paulo, Brazil
Abstract
There is inconclusive evidence.
This abstract is prepared and maintained by Midentistry, currently published in The MI Compendium, 3rd edition, Copyright © 2009 Midentistry. The full data of this review is available in http://www.midentistry.com/secure-folder/content/3/mic12D3.asp (ISBN: 0-620-34080-0)
This record should be cited as: Mickenautsch S, Yengopal V, Bonecker M, Oliveira LB. Salivary buffer and diabetes. Minim Interv Comp Database Syst Rev 2008; 1: RV02620080105.
This version first published online: January 30, 2008
Last revised: April 30, 2008
Objectives
To assess whether diabetes is associated with the salivary buffer activity.
Search strategy
The trials were identified from a search of the PubMed database on: January 5, 2008 using the terms: "("Diabetes Mellitus"[Mesh] OR "Diabetes Mellitus, Type 2"[Mesh] OR "Diabetes Mellitus, Type 1"[Mesh] OR "Diabetes Mellitus, Experimental"[Mesh] OR "Diabetes Mellitus, Lipoatrophic"[Mesh]) OR ("Diabetes Mellitus"[Mesh] OR "Diabetes Mellitus, Type 2"[Mesh] OR "Diabetes Mellitus, Type 1"[Mesh] OR "Diabetes Mellitus, Experimental"[Mesh] OR "Diabetes Mellitus, Lipoatrophic"[Mesh]) AND Salivary buffer activity and a search of the LILACS database on: March 25, 2008 using the terms: "diabetes mellitus AND saliva"
Inclusion criteria
All in-vivo or in-situ randomized/quasi-randomized control trials; case control trials (CCT) and COHORT studies with relevance to review question; published in English or Portuguese.
Data collection and analysis
The systematic literature search identified 5 articles in compliance with the broad inclusion criteria. Of these, 1 article was rejected due to insufficient internal validity. Four articles were accepted for data extraction and further meta-analysis. Clinical, methodological and statistical heterogeneity between studies was observed. One further study could not be included for meta-analysis due to missing standard deviation (SD). Meta-analysis was conducted using the remaining 3 articles.
Main results
The results show a weighted mean difference (WMD) of the buffer capacity between non-diabetics and diabetics of 0.10 (0.07 - 0.14). Statistical heterogeneity was observed.
Authors' conclusions
In light of existing heterogeneity, low number of articles and low weighted mean difference, the result provides an inconclusive answer to the question, whether the saliva buffer capacity is associates with diabetes. In order to answer the review question more studies are needed.
